NUCB2 and erectile dysfunction: Consequently, this restoration of the normal contractile function of corpus cavernosum smooth muscle is indicative of the therapeutic potential of Nesfatin-1 in T2DMED.Studies [34] have pointed out that impaired NO activity released by cavernous endothelial cells is an important cause of erectile dysfunction, and excessive damage of NO to cavernous endothelial cells under pathological conditions is the main mechanism of ED induced by NO-CGMP pathway.