A series of these impairments, including portal hypertension, arterial vasodilation, ascites, hypotension, increased cardiac output, hypovolemia, activation of the renin-angiotensin-aldosterone system, and renal vasoconstriction, are considered to contribute to the development of kidney injury and renal dysfunction in the context of cirrhosis [123–125]. This evidence concerns the gene REN and portal hypertension.