APP and Alzheimer disease: Monsonego et al. [138] reported that compared with MHCII- microglia, Abeta-Th1 cells polarized to secrete IFN-gamma and injected intracerebroventricularly (i.c.v.)into 5×FAD mice with AD induced the differentiation of MHCII+ microglia with distinct morphologies and improved plaque clearance capacity [138].