BACE1 and Alzheimer disease: Exposure to high temperatures, serum starvation, streptozotocin, Aβ1-42, high glucose, BACE1-AS, and BACE1 mRNA upregulate BACE1-AS expression, suggesting that the increase in BACE1-AS expression may be associated with cellular stressors that drive the upregulation of BACE1 mRNA and protein levels, thereby promoting the biosynthesis of Aβ1-42 in the human AD brain [37].