To test the effects of sparsentan compared with losartan on endogenous kidney tissue remodeling in FSGS, as described in the physiological condition (Figure 3), Ren1d-Confetti and Cdh5-Confetti mice were crossed with Pod-TRPC6-Tg mice to track the fate of cells of the renin lineage or endothelium, respectively. This evidence concerns the gene REN and focal segmental glomerulosclerosis.