EDN1 and focal segmental glomerulosclerosis: Although very few glomerular hemodynamic and GFB parameters were altered by losartan treatment, AT1R blockade by losartan inhibited ET-1+AngII–induced elevations in AA VSMC (in physiological model) and podocyte (in FSGS model) calcium (Figure 2C and Figure 4B) and improved glomerular capillary blood flow in the FSGS model (Figure 4H).