An effect of GLP-1 receptor agonists on suicidality is plausible, as GLP-1 receptors are present in the central nervous system and GLP-1 receptor agonists have been shown to cross the blood-brain barrier.2,3 Previous studies have linked bariatric surgery and weight-reduction drugs to a potentially increased risk of suicide and self-harm.4,5 Conversely, it has also been suggested that GLP-1 receptor agonists may protect against depression. This evidence concerns the gene GLP1R and depressive disorder.