The first vaccines belonging to this family used viral DNA and RNA backbones (poxvirus, adenovirus, Castle virus, etc.)engineered to express the genes of known tumor target antigens/co-accessory molecules’ (B7.1, ICAM-1 LFA-3, CD40, TRICOM- PSA and TRICOM CEA) and/or proinflammatory cytokines (GM-CSF, IL12). This evidence concerns the gene CD80 and neoplasm.