CD40LG and monoclonal gammopathy: In autoimmune polyneuropathies, high titers (> 1/8000) of anti-sulfatide IgM are associated with chronic, typically sensorimotor, autoimmune neuropathy (i.e., CIDP) and the concurrent presence of IgM monoclonal gammopathy in polyneuropathy, while low titers are associated with various neuropathies (1/8000) or show a similar distribution across all patients (1/4000) (0 normal subjects for 1/4000) [1].