Taken together, these results suggested a positive feedback loop of OMD/BMP2/BMPR1A/RUNX2/OMD promoting the osteogenic‐like differentiation of hRIFs, through which OMD induced the osteogenic‐like microenvironment of renal interstitium to participate in RP formation (Figure 10A,B). Here, RUNX2 is linked to occult macular dystrophy.