Taken together, these results suggested a positive feedback loop of OMD/BMP2/BMPR1A/RUNX2/OMD promoting the osteogenic‐like differentiation of hRIFs, through which OMD induced the osteogenic‐like microenvironment of renal interstitium to participate in RP formation (Figure 10A,B). The gene discussed is BMPR1A; the disease is occult macular dystrophy.