Our study for the first time identified OMD as a potential marker for renal interstitial biomineralization in RP tissues, and revealed a novel feedback loop of OMD/BMP2/BMPR1A/RUNX2/OMD driving hRIFs to adopt osteogenic‐like fates, by which OMD induced osteogenic‐like microenvironment to participate in RP formation. This evidence concerns the gene BMP2 and retinitis pigmentosa 1.