SREBF1 and cancer: SREBPs regulate the expression of factors involved in the uptake and synthesis of cholesterol, fatty acids, and phospholipids.[26] Dysregulation of SREBPs is frequently associated with hyperactive fatty‐acid synthesis and lipogenesis pathways in cancers.[24] In this family, SREBP1 primarily stimulates the synthesis of fatty acid, while SREBP2 predominantly acts on cholesterol biosynthesis genes.[27] SREBPs can bind to the promoter region of key genes involved in lipid metabolism, thereby increasing lipid biosynthesis.