TP53 and endometrial serous adenocarcinoma: In a carefully controlled cohort study of tubal ligation, the hazard ratio for type I endometrioid uterine cancer was 0.78, but the HR was strikingly 0.25 for type II, typically p53-mutant uterine serous carcinoma, indicating surprisingly low incidence of type II tumors following tubal ligation (65).