High LGR5 expression has also been significantly associated with poor overall survival (OS; HR, 1.87; 95% CI, 1.23–2.84; P = 0.003) and with worse disease-free survival (DFS; HR, 2.44; 95% CI, 1.49–3.98; P = 0.001) in the recently published colorectal cancer meta-analysis (48). Here, LGR5 is linked to colorectal cancer.