ZNF8 and neoplasm: Recent studies have also demonstrated that the infiltration of neutrophils in distant organs also plays a role in this process of metastasis, as it facilitates the creation of a microenvironment that is favorable for tumor colonization, commonly referred to as the premetastatic niche.[29] Notably, our results showed that ZNF8 could specifically induce neutrophil infiltration, particularly in early metastatic organs, by promoting the transcriptional activation of neutrophil chemokines.