SMAD4 and breast cancer: reported that SIRT7 modulates TGF‐β signaling and suppresses of breast cancer metastasis by deacetylating and promoting Smad4 degradation.[9] However, the exact mechanisms by which the TGF‐β pathway underlies lung metastasis in breast cancer remain incompletely understood, and there is still a lack of effective treatments targeting the TGF‐β pathway to suppress lung metastasis in breast cancer patients.