ZNF8 and breast cancer: To investigate the correlation between ZNF8 expression and different metastasis status of breast cancer, we studied another cohort comprising 44 patients without metastasis and 66 patients with metastatic breast cancer (Table S2, Supporting Information), and found a substantial increase in ZNF8 expression among breast cancer patients with lung, bone, liver and brain metastasis, especially those with lung metastasis (Figure 2E).