REN and hypertensive disorder: UK NICE guidelines recommend tailoring of antihypertensive treatment for chronic hypertension in non-pregnant adults on the basis of ethnicity and age (NG136, updated 2019) [27] on the premise that there is a higher prevalence of low-renin hypertension in individuals of African ancestry [100,101] leading to an attenuated response to beta-blockers and angiotensin converting enzyme inhibitors (which work primarily by suppressing the renin-angiotensin system), and better response to calcium channel blockers (which work primarily by vasodilation).