In this study, astrocytic IL‐3 and microglial IL‐3R were found to be responsive to α‐synuclein pathology in the brains of transgenic A53T PD mice and in an adeno‐associated virus (AAV)‐human α‐synuclein (AAV‐hα‐Syn)‐injected PD mouse model. This evidence concerns the gene IL3RA and Parkinson disease.