IL‐3 has been demonstrated to be protective in AD through the clearance of Aβ and tau.[8] However, recent evidence has also revealed that astrocytic and T‐cell IL‐3 induce inflammatory responses and recruit IL‐3Rα+ myeloid cells to aggravate multiple sclerosis (MS).[11] Thus, the role of IL‐3 signaling in PD remains unclear. This evidence concerns the gene MAPT and Alzheimer disease.