In recent years, various types of nanoparticles have been used in detection and treatment for inflammatory diseases.[21, 22, 23] Recent studies have shown that MPO is wildly expressed in the inflammatory sites.[24, 25, 26] Therein, MPO‐responsive biomaterials via bioluminescence resonance energy transfer (BRET) can be used for inflammation imaging or tumor therapy through BRET‐mediated photodynamic therapy.[24, 25, 26] However, the use of BRET‐based nanomedicine to treat infective diseases has not yet been investigated and the unique advantages of such applications remain to be demonstrated. This evidence concerns the gene MPO and neoplasm.