CD8A and hepatocellular carcinoma: In the context of tumor development, the introduction of CD8+ T cells into B16 mice revealed distinct differentiation and functionalities of the DPT cells, emphasizing the adaptive nature of lineage commitment mechanisms within the peripheral environment.[36] The TCR analysis of tumor‐infiltrated T cells in HCC patient samples indicated that the DPT cells likely originated from the same lineage as CD8 SPT cells, suggesting a probable transformation of DPT cells from intra‐tumoral SPT cells.[37] In our study, we conducted a comparison of cell markers and differentially expressed genes.