Our recent study has revealed that the Arf1‐regulated lipid metabolism plays a crucial role in sustaining the homeostasis of cancer stem cells and neurons selectively.[2, 6, 7, 8, 9, 10] In Drosophila, the knockout of Arf1 in differentiated cells of the intestine and Malpighian Tubules (kidney) yields no discernible phenotype. Here, ARF1 is linked to cancer.