We further performed GSEA analysis on the feature genes of these four (CD8 SPT, CD4 SPT, DPT, and DNT) T cell types, and found that DPT cells had superior characteristics in response to tumor cells, MHC protein binding, αβ T cell activation, and T cell selection, suggesting that DPT cells were more activated and probably had stronger anti‐tumor ability (Figure 6a; Figure S10a, Supporting Information). Here, CD8A is linked to neoplasm.