PDCD1 and hepatocellular carcinoma: Nevertheless, recent research has indicated the presence of these cells in various human tumors, particularly in the leading‐edge area, which is situated adjacent to the malignant‐benign boundary of human hepatocellular carcinoma (HCC).[36, 37] Human hepatocellular carcinoma (HCC) DPT cells demonstrate a high expression of PD‐1 and exhibit an activated phenotype along with robust functionality.