Its role involves coordinating organelle communication, fatty acid metabolism, and maintaining mitochondrial homeostasis.[1] Research has revealed high expression of Arf1 in various types of human cancers, including but not limited to breast, hepatocellular, colon, and prostate cancer.[2, 3] And, elevated Arf1 expression is inversely linked to the prognosis of individuals diagnosed with cancer.[2, 4, 5]. The gene discussed is ARF1; the disease is prostate carcinoma.