Several studies have shown that CD8+ T cells that highly express HLA‐DR, CD38, and inhibitory markers, such as PD‐1 and TIGIT, are active subsets and persist in patients with severe virus infection disease[12] or patients who receive immune therapy.[13] However, other studies have shown that CD8+HLA‐DR+ T cells suppress the immune response in vitro.[14] Here, in our study, we found that CD8 Trp cells highly express HLA II‐related genes while expressing low levels of CD38 (Figure S2A,B, Supporting Information). The gene discussed is CD38; the disease is viral infectious disease.