Our recent study also reported that adeno‐associated viral vector (AAV) serotype 9‐CMV‐Bmi‐1‐RING1B could promote the ubiquitination of GATA4 and prevent GATA4‐dependent senescence‐associated pathological cardiac hypertrophy.[19] A previous study showed that eight serotypes of AAV, including 1, 4, 5, 6, 7, 9, rh10, and rh39, were successfully infected into osteoblasts in vitro. This evidence concerns the gene RNF2 and cardiac hypertrophy.