SMPD1 and Peripheral demyelination: After SCI, axonal growth and circuit reorganization are determined by the autonomous mechanisms of neurons and the interactions between neurons, glial cells, immune cells, and other cells.[90] Prior research has demonstrated that the inhibition of ASMase leads to a significant increase in the number of oligodendrocytes, thereby promoting myelin repair in cases of acute and chronic demyelination.[91] Therefore, the role of NBD peptide in treating SCI in other cells is also worth exploring.