An earlier investigation demonstrated that the LMP pathways and consequent translocation of CTSB from lysosomes to the cytosol are signaling mechanisms that trigger pyroptosis.[53] Moreover, there is growing evidence indicating that lysosomal impairment can hinder the proper flux of autophagy in neurological disorders, resulting in the accumulation of autophagosomes in neurons.[54, 55] Given the profound effect of NBD peptide on pyroptosis suppression and autophagy flux in neurons in this study, we postulated that NBD peptide could affect lysosomal functionality in neurons after SCI. Here, PDLIM7 is linked to nervous system disorder.