Although some genetic polymorphisms, namely PNPLA3, TM6SF2 and MBOAT7, represent critical determinants in the pathogenesis of liver steatosis and in the progression of liver damage and could be used in this diagnostic setting, very few studies have explored the role of their combination in MASLD diagnosis and in the prediction of evolving disease.40 The gene discussed is PNPLA3; the disease is fatty liver disease.