Additionally, when we analyzed tumor and CD8+ T cells from untreated B16 tumors after 2 weeks of progression ex vivo, Ki67 expression strongly correlated with LDH and GLUT1 expression in B16 tumor cells, but this correlation was less apparent in CD8+ TILs, suggesting that the glycolytic markers LDH and GLUT1 may be more important for tumor cell proliferation than T cell proliferation (Supplemental Figure 4E). This evidence concerns the gene CD8A and neoplasm.