Genes involved in glycolysis (ALDOA, LDHA, PGK1, PFKL, PGM1) and other metabolic processes (GPX4, PRDX4, ACO2, ASPH, IDH2, SQLE, NPC2, SPTSSA) were upregulated in primary tumor cells, suggesting that the metabolism in primary tumors was distinct from that in their matched metastasis. This evidence concerns the gene SQLE and neoplasm.