In contrast, among the 91 genes upregulated in metastatic cells from highly metastatic tumor models, many genes were indicative of high stress-response signaling, including several heat shock proteins (HSPB1, HSPA8, HSPA6, HSPH1, HSP90AB3P, DnaJs A1, B1, C3, and BAG3), PPM1G, and genes involved in DNA damage repair (SSRP1, NONO). This evidence concerns the gene HSPA8 and neoplasm.