This is reminiscent of dominant mutations in CXCR4, responsible for WHIM (warts, hypogammaglobulinemia, immunodeficiency, and myelokathexis) syndrome, that lead to enhanced and prolonged β integrin activation responsible for accumulation of mature and degenerating neutrophils in the BM (50). The gene discussed is CXCR4; the disease is immunodeficiency disease.