In Columbia-GN and Columbia-CKD, high-risk APOL1 genotypes were associated with an increased risk of kidney failure, while CureGN showed a nonsignificant trend toward increased risk (HR = 1.72, 1.74, and 1.28; P = 0.018, 1.14 × 10–6, and 0.31, respectively; Table 3). Here, APOL1 is linked to chronic kidney disease.