High-risk APOL1 genotypes were more common in individuals with FSGS (OR = 8.86 and 5.27; P = 4.19 × 10–9 and 0.033 in CureGN and Columbia-GN, respectively), hypertension-associated kidney disease (OR = 2.12, P = 0.024), and those who self-identified as Black/African American (OR = 167, 28.88, and 16.92; P = 3.49 × 10–25, <2 × 10–16, and <2 × 10–16 in CureGN, Columbia-GN, and Columbia-CKD, respectively) or Latinx (OR = 2.46, 6.03, and 1.83; P = 0.047, 1.70 × 10–5, and 0.014 in CureGN, Columbia-GN, and Columbia-CKD, respectively; Supplemental Table 5). This evidence concerns the gene APOL1 and Hypertension.