In our previous studies, we found that the expression of RabGGTase is lower in the spinal cord motoneurons in SOD1G93A mice compared with WT mice, and autophagy defects could be ameliorated by modulating RABGGTB in neurons (25), Rab geranylgeranyltransferase subunit alpha (RABGGTA) and Rab geranylgeranyltransferase subunit beta (RABGGTB) composed RabGGTase (26) that mediated the prenylation modification of Rab7, which was inhibited in the ALS model (27). The gene discussed is RABGGTB; the disease is amyotrophic lateral sclerosis.