SHMT2 and cancer: These are of particular importance for inhibitor design, as SHMT is a target for antibacterial, antimalarial, anti-cancer, and herbicide agents (Schwertz et al., 2017, 2018; Batool et al., 2020; Cuthbertson et al., 2021; Zarou et al., 2021; Makino et al., 2022; Jin et al., 2023; Situ et al., 2023; Li et al., 2024).