CTNNB1 and hepatocellular carcinoma: From a molecular perspective, HCC is caused by the accumulation of multiple genomic and epigenomic alterations, which commonly include oncogenic mutations in the TERT promoter, AXIN1, TP53, and CTNNB1; amplification of chromosome 1q, 8q; and loss of 8p, 22p (Craig et al., 2020).