It is suggested that the combined action of 6-shogaol and curcumin against hepatocellular carcinoma may be related to the inhibition of PI3/AKT and MAPK signalling pathways, upregulation of Bax and Caspase-3 proteins, and downregulation of Bcl-2, Cyclin-B, and CDK-1 proteins. This evidence concerns the gene PI3 and hepatocellular carcinoma.