It was found that the core targets such as PTGS2, CXCL8, TGFB1, and STAT3 were mainly enriched in the pathways related to cancer and several inflammatory factors, and that tretinoin and PTGS2 as well as tretinoin and PTGS2, CXCL8, and STAT3 had strong binding activities (Liu et al., 2021). Here, STAT3 is linked to cancer.