TP53 and hepatocellular carcinoma: Many molecular pathways have been implicated in HCC carcinogenesis, including TERT promoter mutations, Wnt/β-linked protein, P53, Akt/mTOR, vascular endothelial growth factor receptor (VEGFR) and endothelial growth factor receptor (EGFR)/RAS/MAPK pathways (Zhang et al., 2020).