The results of GO enrichment analysis (Figure 2E) indicated that the key targets for the interaction of 6-shogaol and curcumin with hepatocellular carcinoma were mainly involved in the negative regulation of apoptotic process, positive regulation of transcription, signal transduction, RNA polymerase II promoter transcription positive regulation, epidermal growth factor receptor signaling pathway, learning and memory, cell proliferation, gene expression, and other biological processes. The gene discussed is EGFR; the disease is hepatocellular carcinoma.