Almost 75% of MN are primary MN, and most of them involve antibodies against a podocyte antigen, PLA2R.3 Secondary MN can be attributed to various etiologic factors, including autoimmune diseases, infections, malignancies, and medications.5 IgG4-RD is a well-recognized fibroinflammatory condition affecting multiple organs, including the kidneys. The gene discussed is PLA2R1; the disease is autoimmune disease.