AKT1 and cancer: Serotonin has also been demonstrated to support immune surveillance against cancer. In our previous study, we showed that dopamine inhibited the pro-inflammatory pathways through the attenuation of Ak strain transforming (Akt) signaling axis in KERATIN-forming tumor cell line HeLa (KB) cell lines [14]. The present study aimed to analyze the effect of serotonin on KB cells based on Akt signaling members.