GTPBP1 and stroke disorder: These findings underscore the potential of MRI-based risk stratification tools to optimize secondary prevention efforts and reduce recurrent strokes, the promise of ultra-high-field MRI for advancing cerebrovascular diagnostics, the utility of 18F-GP1 PET imaging for non-invasive thrombus detection, and the critical role of BBB dysfunction in the pathophysiology of cSVD, contributing to the progression of white matter hyperintensities, lacunar infarcts, and other neurovascular abnormalities.