Numerous studies have shown that multiple exposures to METH significantly impair cognitive function, leading to long-term memory deficits (116), whereas resveratrol may be effective in preventing memory impairment through interaction with Keap1, activation of the Keap1-Nrf2 pathway, and inhibition of DNA damage and apoptotic responses after METH exposure (98). The gene discussed is KEAP1; the disease is memory impairment.