In summary, the deficiency in GSDMD did not exert an impact on tumor growth, immune cell infiltration, or the immune landscape in either the EO771 breast cancer or the Hepa1-6 hepatoma model, although intratumoral Cxcl10 levels were elevated in Hepa1-6 tumors grown in Gsdmd-/- mice. This evidence concerns the gene CXCL10 and hepatocellular carcinoma.