CASP1 and neoplasm: The role of the inflammasome itself in EO771 tumors is however controversial, as in one study EO771 tumor growth was reduced in mice deficient for essential components of the inflammasome, caspase 1 or NLRP3 (24), whereas in another study tumor growth was independent of NLRP3 and of GSDMD, as seen in our study (40).