Our protein-protein interaction (PPI) analysis revealed interactions between our identified hub IRGs and other immune genes, which raises the possibility of a connection between these IRGs, CXCL8, and the receptors CXCR4 and CX3CR1. This interconnectedness could indicate a complex signaling network within LN pathogenesis, where CXCL8, CXCR4, and CX3CR1 may interact to regulate immune responses and cellular dynamics in the kidney. Here, CXCR4 is linked to lobular neoplasia.