This degenerative disease is associated with lower serum BDNF levels (Karege et al., 2002a), which can be elevated to a basal level through antidepressant therapy (Shimizu et al., 2003), as has been established by recent meta-analyses (Zhou et al., 2017; Shi et al., 2020). The gene discussed is BDNF; the disease is neurodegenerative disease.