MAPT and early-onset autosomal dominant Alzheimer disease: Studies have shown that ROS-induced cofilin oxidation can induce oxidative stress in ischemic and hemorrhagic strokes (Alhadidi et al., 2016), and the oxidative stress-induced increase in cofilin dephosphorylation is linked to the accumulation of tau tangles and amyloid beta plaques in Alzheimer's disease (Namme et al., 2021).