The results of our studyshowed that theincrease in thyroid volume was consistent with the increase in anti-TPO antibody titers.In general,the role of anti-TPO antibodies in the tissue destruction process associated withhypothyroidism dueto Hashimoto's thyroiditis has been proven, and its cytotoxic effects on thyroid cellsacceleratethyroid dysfunction due to complement fixation strength [5]. Here, TPO is linked to Hashimoto thyroiditis.