Of the few studies that evaluatedtherelationship between anti-Tg antibody titer and hypoechogenicity, none has found anysuchassociation [19][20].It is still arguable whether all patients with autoimmune thyroid diseases are atincreased risk fornodules and thyroid cancer or whether certain thyroid characteristics increase this risk[21]. The gene discussed is TG; the disease is thyroid gland carcinoma.