PDE5A and cancer: High expression of PDE5 may play an importantrole in cancer.Bogucka-Kocka and colleagues [38] showed thatLovagehydroalcoholic extract had a cytotoxic effect on nine cell lines of human leukemia.Furthermore,Sargazi et al. [39] conducted a study toinvestigate thecytotoxic effects of lovage extract on DU-145 and PC-3 cell lines.