Uponstimulation, I-Bs are phosphorylated and degraded, releasing NF-κB proteins fromtheirinhibitory influence and allowing them to move into the nucleus [44][45].COX-2 is induced bycytokines and growth factors and converts arachidonic acid to prostaglandin H2.Numerous studieshave shown that COX-2 plays a significant role in regulating cancer-relatedprocesses such asapoptosis, invasiveness, and angiogenesis [46][47]. This evidence concerns the gene NFKB1 and cancer.