This activation can contribute to tumor formation by promoting cell growth andangiogenesis,inhibiting cell death, and facilitating cell invasion and metastasis [27][44].NF-κB dimers are associatedwith NF-κB protein inhibitors (I-Bs), including IKKa, IKKb, and IKK/NEMO, in thecytosol. Here, CHUK is linked to neoplasm.