In previous studies [13,14], we performed gene chip analysis on neonatal rats colon cancer tissues and found that after being stimulated by TGF-β1, a variety of microRNAs (miRNAs) with significant differences, such as miRNA-29a, miR-1269a, miR-135b and miR-21, could be affected by BBR to varying degrees. Here, TGFB1 is linked to malignant colon neoplasm.