It furthermore had a negative effect on progesterone synthesis in porcine granulosa cells [100] and selectively inhibited human monoamine oxidase-A (MAO-A) with an IC50 value of 1.71 μM (but did not inhibit MAO-B) and was thus considered for the treatment of depression, Parkinson’s disease, and Alzheimer’s disease [116]. The gene discussed is MAOA; the disease is early-onset autosomal dominant Alzheimer disease.