Studies have found that pregnenolone sulfate (PREGS) and dehydroepiandrosterone sulfate (DHEAS) are significantly lower in elderly AD patients compared to age-matched non-demented controls, particularly in the striatum, cerebellum, and hypothalamus, and negatively correlated with high levels of cortical Aβ and phosphorylated tau proteins (Weill-Engerer et al., 2002), where PREGS and DHEAS are types of steroids. The gene discussed is MAPT; the disease is Alzheimer disease.