For instance, HIF‐1α induced NR2F1‐AS1 upregulation in pancreatic cancer (PC) and highly expressed NR2F1‐AS1 promoted PC cell proliferation, migration, and invasion by modulating the expression of its sense gene NR2F1, which activates the AKT/mTOR pathway in PC.33 This evidence concerns the gene NR2F1 and pachyonychia congenita.