SIRT6 and non-small cell lung carcinoma: To verify our hypothesis, we first compared the expression of mitoAMPK, MZF1, SIRT6, and Warburg effect‐related genes between NSCLC cell lines and normal lung epithelial cells; then, we confirmed the function of MZF1 and SIRT6 in regulating glycolysis and the NSCLC cell phenotype.