In NSCLC, numerous factors have been proven to be related to the Warburg effect: OTUB2 could bind to and deubiquitinate U2AF1 and consequently promote NSCLC progression,3 and α‐Hederin could inhibit glycolysis in A549 and H460 cells by activating SIRT6.17 Here, OTUB2 is linked to non-small cell lung carcinoma.