CRP and inflammatory bowel disease: Shreds of evidence relating let-7b with IBD are still scarce, and if any, they are associated with CD.50–52 Noteworthy, its mucosal overexpression has been correlated with C-reactive protein (CRP) levels, a biological marker of inflammation.53 Here, oral administration of let-7b to WT mice was sufficient to induce low-grade chronic inflammation characterized by the mRNA expression linked with the presence of macrophages.