According to the National Institutes of Health (NIH) COVID-19 treatment guidelines, IL-6 inhibitors (sarilumab, tocilizumab) and Janus kinase (JAK) inhibitors (baricitinib, tofacitinib) are currently used in the treatment of severe COVID-19 cases that require supplemental oxygen, high-flow oxygen, noninvasive ventilation (NIV), mechanical ventilation, or extracorporeal membrane oxygenation (ECMO) [27]. The gene discussed is IL6; the disease is COVID-19.