While the role ATO in SCLC is less reported, APA (TKI) was found to retard the growth of SCLC cells by downregulating the expression of VEGF, P-VEGFR2, P-PI3K, P‐Akt, P‐ERK1/2, Ki‐67 and CD31 [13]. The gene discussed is AKT1; the disease is small cell lung carcinoma.