NR4A1 and neoplasm: Recent studies ae starting to address these knowledge gaps; in a recent analysis of the TAILORx trial of over 10,000 women with hormone receptor-positive, node-negative breast cancer, locoregional recurrence was significantly higher in Black women after adjustment for treatment, patient and tumor characteristics (HR = 1.78 (1.15–2.77)) compared to White women [38]confirming that there are latent features that are not measured by routine clinical variable that nevertheless impact important outcomes.