These findings are in line with recent observations by Zhong et al., who demonstrated that upregulation of NLRP3 expression in the murine AML cell line C1498 leads to increased expansion of leukemic cells in the BM, liver, and spleen, and shortens survival of lethally irradiated C57BL/6J recipient mice [10]. The gene discussed is NLRP3; the disease is acute myeloid leukemia.