Important evidence for involvement of NLRP3 — a central hub of innate immunity that mediates the release of pro-inflammatory mediators — in human cancers emerged from a study showing that 15 out of 24 disparate, mostly solid, cancers had significantly different expression profiles of NLRP3 and other inflammasome-related genes compared to normal tissue [33]. The gene discussed is NLRP3; the disease is cancer.