TNF and acute myeloid leukemia: In accordance with the reduced survival of ΔNLRP3 leukemia cells in recipient mice (Fig. 5D), analysis of serum showed significantly lower secretion of human growth factors and cytokines such as TNFα, PIGF-1, HGF and the inflammasome-related cytokine IL-18, known to have a vital role in AML, when compared to control recipient mouse serum (Suppl.