Analysis of AML patient survival revealed a significantly higher median overall survival among patients with low NLRP3 expression (n = 39) compared to those with high (n = 40) NLRP3 expression (NCBI-GEO GSE12417) (Fig. 1F), supporting the hypothesis that NLRP3 plays a critical role in AML pathogenesis. The gene discussed is NLRP3; the disease is acute myeloid leukemia.