TNF and myeloid sarcoma: Studies in EAE models and MS brain lesions, have shown that EAATs, including EAAT2, [21, 43, 44] are reduced in CNS, predominantly in astrocyte, and that EAAT downregulation induced by inflammatory stimuli, such as interleukin 1β and TNFα, is associated with altered glutamate uptake [45, 46].