SLC1A2 and relapsing-remitting multiple sclerosis: Importantly, proteomic analysis performed in separated samples of SEC EV 20K and SEC EV 100K of three relapsing RRMS patients showed that the majority of proteins found associated with relapse, including EAAT2 protein, were detected in SEC EV 20K but not in SEC EV 100K samples, as reported in Venn diagram in Supplementary Fig. 7.