We first analysed the DA1-3b leukemia model and among the 70 commonly mutated genes in dormant leukemia DA1-3b/D365 and parental DA1-3b cells, ten genes (Ttc7b, Dnmt3b, Ap1b1, Ne1, Nedd4, Acy1, Cyp11a1, Htr2c, Magee1 and Gdi1) were amplified in dormant and parental cells (Fig. 2A). The gene discussed is NEDD4; the disease is leukemia.